FB2026_03 , released September 17, 2026
Allele: Dmel\vasW660E
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General Information
Symbol
Dmel\vasW660E
Species
D. melanogaster
Name
FlyBase ID
FBal0325118
Feature type
allele
Associated gene
Dmel\vas
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Dehghani and Lasko, 2016)
Mutagen
CRISPR/Cas9
(Dehghani and Lasko, 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: W660E.

(Dehghani and Lasko, 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:15,074,155..15,074,157 [+]
Nucleotide change:

TGG15074155GAA

Reported amino acid change:

W660E

Comment:

W660 (TGG) was substituted with Glu (GAA).

(Dehghani and Lasko, 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from vasW660E homozygous as well as vasW660E/vasPH165 transheterozygous mothers fail to form pole cells or have only drastically reduced number of them. Progeny of vasW660E homozygous females show impaired embryonic patterning (assessed by no. of ftz stripes).

      The number of eggs produced by either vasW660E homozygous or vasW660E/vasPH165 females is comparable to wild-type but the eggs display frequent dorsal appendage defects.

      (Dehghani and Lasko, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vasW660E
      (Dehghani and Lasko, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)