FB2026_03 , released September 17, 2026
Allele: Dmel\vasW660F.EGFP
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General Information
Symbol
Dmel\vasW660F.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0325120
Feature type
allele
Associated gene
Dmel\vas
Associated Insertion(s)
Carried in Construct
P{vas.W660F.EGFP}
Key Links
Transgenic product class
missense_variant
(Dehghani and Lasko, 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Dehghani and Lasko, 2016)
Mutagen
in vitro construct
(Dehghani and Lasko, 2016)
Progenitor genotype
Carried in construct
P{vas.W660F.EGFP}
Cytology
Description

Full-length vas cDNA with a conservative amino acid replacement of the conserved C-terminal Trp660 (W660F) and N-terminal tagged EGFP.

(Dehghani and Lasko, 2016)
Allele components
Component
Use(s)
Encoded product / tool
vas
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      vasW660F.EGFP partially rescues vas1

      (Dehghani and Lasko, 2016)

      vasW660F.EGFP partially rescues vasPH165

      (Dehghani and Lasko, 2016)
      Comments

      The loss of pole cells and patterning defects (assessed by no. of ftz stripes) characteristic for embryos from vas1 homozygous mothers is almost fully rescued in progeny from vas1;vasΔ15-75.T:Avic\GFP-EGFP females.

      The reduced number of eggs laid by vasPH165 homozygous females as well as the dorsal appendage defects in the eggs produced are strongly improved by maternal combination with vasW660F.T:Avic\GFP-EGFP.

      (Dehghani and Lasko, 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      vasW660F.EGFP
      vasW660F.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)