FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pde4UAS.all
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General Information
Symbol
Dmel\Pde4UAS.all
Species
D. melanogaster
Name
FlyBase ID
FBal0325388
Feature type
allele
Associated gene
Dmel\Pde4
Associated Insertion(s)
Carried in Construct
P{UAS-Pde4.all}
Key Links
Transgenic product class
wild_type
(Ruppert et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ruppert et al., 2017)
Mutagen
in vitro construct
(Ruppert et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Pde4.all}
Cytology
Description

UAS regulatory sequences drive expression of the coding sequence for the PDE domain and UCR2 present in all dnc transcripts.

(Ruppert et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pde4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Pde4.RA/Pde4UAS.all rescues Pde4Δ143

      (Ruppert et al., 2017)

      Scer\GAL4Pde4.RA, Pde4UAS.all, Scer\GAL80ple.PK rescues Pde4Δ143

      (Ruppert et al., 2017)

      Pde4UAS.all/Scer\GAL4NP6510 rescues Pde4Δ143

      (Ruppert et al., 2017)
      Fails to rescue

      Pde4UAS.all/Scer\GAL4GMR58E02 fails to rescue Pde4Δ143

      (Ruppert et al., 2017)
      Comments

      The reduced ability of dncΔ143 mutant adults to develop tolerance to ethanol upon re-exposition is rescued by expression of dncScer\UAS.all when driven by either Scer\GAL4dnc.RA (alone or combined with Scer\GAL80ple.PK to restrict the expression pattern) or Scer\GAL4NP6510 but not when driven by Scer\GAL4GMR58E02.

      (Ruppert et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pde4UAS.all
      dncScer\UAS.all
      dncUAS.all
      Name Synonyms
      Secondary FlyBase IDs
        References (1)