FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Poc1W45R
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General Information
Symbol
Dmel\Poc1W45R
Species
D. melanogaster
Name
FlyBase ID
FBal0325420
Feature type
allele
Associated gene
Dmel\Poc1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Khire et al., 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: W45R.

(Khire et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:13,389,740..13,389,740 [-]
Nucleotide change:

T13389740A

Amino acid change:

W45R | Poc1-PA; W45R | Poc1-PB

Reported amino acid change:

W45R

Comment:

T to A or C mutation at the first base of the Trp (TGG) codon leads to an Arg.

(Khire et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Poc1W45R adults display morphological sperm defects but their locomotor behavior appears unaffected (suggesting sensory cilia function is not perturbed).

      Embryos fathered by Poc1W45R mutant males during their first mitosis show monopolar spindles that lack the microtubule aster (although astral microtubules do form eventually in some embryos) but have two centrioles at this pole. These embryos display a dramatic developmental delay, developmental arrest at the cleavage stage and the blastoderm stage and their hatching rate is reduced by about 50%.

      (Khire et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Poc1W45R is rescued by Poc1ABGFP

      (Khire et al., 2016)
      Comments

      The mitotic spindle defects (monopolar spindle) observed in embryos fathered by Poc1W45R mutant males are rescued by paternal expression of Poc1ABGFP.

      (Khire et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Poc1W45R
      poc1W45R
      (Khire et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)