FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Poc1ABGFP
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General Information
Symbol
Dmel\Poc1ABGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0325416
Feature type
allele
Associated gene
Dmel\Poc1
Associated Insertion(s)
Carried in Construct
P{gPoc1ABGFP}
Key Links
Transgenic product class
genomic_DNA
(Khire et al., 2016)
wild_type
(Khire et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Khire et al., 2016)
wild_type
(Khire et al., 2016)
Mutagen
in vitro construct
(Khire et al., 2016)
Progenitor genotype
Carried in construct
P{gPoc1ABGFP}
Cytology
Description

Genomic fragment containing the Poc1 promoter, intron and exons. A GFP tag has been inserted such that it tags the C-terminal end of the Poc1 B isoform, but does not tag the Poc1 A isoform.

(Khire et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Poc1
Encoded product / tool
Poc1
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Poc1ABGFP rescues Poc1W87X

      (Khire et al., 2016)

      Poc1ABGFP rescues Poc1W45R

      (Khire et al., 2016)
      Comments

      The mitotic spindle defects (monopolar spindle) observed in embryos fathered by Poc1W45R mutant males are rescued by paternal expression of Poc1ABGFP.

      Combination with Poc1ABGFP also restores the giant centriole size defect as well as the sperm immotility characteristic for Poc1W87X mutant males. Paternal expression of Poc1ABGFP also significantly rescues the embryonic phenotypes of progeny from Poc1W87X fathers (developmental delay, mitotic defects).

      (Khire et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Poc1ABGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)