FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sp1HR
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General Information
Symbol
Dmel\Sp1HR
Species
D. melanogaster
Name
FlyBase ID
FBal0325675
Feature type
allele
Associated gene
Dmel\Sp1
Associated Insertion(s)
TI{TI}Sp1HR
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Córdoba et al., 2016)
Mutagen
gene targeting by homologous recombination
(Córdoba et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{TI}Sp1HR
Cytology
Description

The third exon of Sp1 (where the DNA-binding domain is located) is replaced with a attP integration site.

(Córdoba et al., 2016)
Allele components
Component
Use(s)
Also carries
attP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sp1HR homozygotes present severe leg defects, including severe shortenings of the leg and its individual segments, joint defects and segment fusions, as compared to controls; Sp1HR homozygous prepupal presumptive fourth tarsal leg segments cells are significantly wider and shorter along the proximodistal axis, without displaying significant differences in apical surface, as compared to controls.

      Sp1HR/Df(1)btd-Sp1 transheterozygotes, in which both Sp1 alleles are affected and one btd allele is deleted, present severe leg defects, including a strong decrease in the size of the leg and its individual segments, joint defects and segment fusions, and arista-like bristles in the distal tip of the leg, as compared to controls.

      Sp1HR homozygous clones that span leg segments result in segment fusion, usually associated with segment shortening, whereas clones occurring near the distal end of leg segments lead to small outgrowths, as compared to controls.

      (Córdoba et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sp1HR
      (Blom-Dahl et al., 2020, Álvarez and Díaz-Benjumea, 2018, Newcomb et al., 2018, Córdoba et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)