FB2026_02 , released June 18, 2026
Allele: Dmel\fandP218
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General Information
Symbol
Dmel\fandP218
Species
D. melanogaster
Name
FlyBase ID
FBal0325715
Feature type
allele
Associated gene
Dmel\fand
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sauerwald et al., 2017)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Sauerwald et al., 2017)

Predicted to result in a truncated protein lacking all of the 13 tetratricopeptide repeats of the fand protein.

(Sauerwald et al., 2017)

Amino acid replacement: W69term.

(Sauerwald et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,593,990..13,593,990 [+]
Nucleotide change:

G13593990A

Amino acid change:

W69term | fand-PA

Reported amino acid change:

W69term

Comment:

Nonsense mutation (TGG to TGA) at Trp codon.

(Sauerwald et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fandP218 homozygotes are embryonic lethal and display defects in primary tracheal branching as the branch outgrowth is severely impaired, defective tracheal branching is also observed in fandP218/fandH124 transheterozygous embryos.

      (Sauerwald et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The tracheal branching defects characteristic for fandP218 mutant embryos are not noticeably improved by expression of CG17716Scer\UAS.cSa in the ectoderm under the control of an unspecified Gal4 driver.

      (Sauerwald et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The fand05488, fandfas-1, fand1 as well as fand2 alleles each fails to complement both fandP218 and fandH124 alleles.

      (Sauerwald et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fandP218
      fasP218
      (Sauerwald et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)