FB2026_02 , released June 18, 2026
Allele: Dmel\β-SpecFY18
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General Information
Symbol
Dmel\β-SpecFY18
Species
D. melanogaster
Name
FlyBase ID
FBal0325726
Feature type
allele
Associated gene
Dmel\β-Spec
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q1046term.

    (Wong et al., 2015)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:17,664,319..17,664,319 [+]
    Nucleotide change:

    C17664319T

    Amino acid change:

    Q1046term | beta-Spec-PA; Q1046term | beta-Spec-PB; Q1046term | beta-Spec-PC

    Reported amino acid change:

    Q1046term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

    (Wong et al., 2015)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The presence of posterior follicle cell β-SpecFY18/β-SpecFY18 clones leads to oocyte polarity defects not associated with any apparent separation of the posterior follicle cells from the oocyte, and oocyte nuclei frequently remain at the posterior end of the oocyte during mid-oogenesis, instead of migrating to the dorsal-anterior corner; β-SpecFY18/β-SpecFY18 posterior follicle cell clones show an increased frequency of hyperplasia, as compared to controls; follicle cells in these clones exhibit aberrant actin cytoskeletal morphology on their basal side, and β-SpecFY18/β-SpecFY18 border cell clones exhibit defective migration, failing to migrate as a cluster of cells, as compared to controls.

        (Wong et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        β-SpecFY18
        β-spectrinFY18
        (Wong et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)