FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mib2S2616
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General Information
Symbol
Dmel\mib2S2616
Species
D. melanogaster
Name
FlyBase ID
FBal0325813
Feature type
allele
Associated gene
Dmel\mib2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Domsch et al., 2017)
Mutagen
ethyl methanesulfonate
(Domsch et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement: D564N.

(Domsch et al., 2017)

The D564N missense mutation hits a conserved residue in the fourth ankyrin repeat.

(Domsch et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,039,662..19,039,662 [+]
Nucleotide change:

G19039662A

Amino acid change:

D564N | mib2-PA; D564N | mib2-PB; D564N | mib2-PC

Reported amino acid change:

D564N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Domsch et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mib2S2616 homozygous late stage 16 embryos display severe loss and detachment of somatic muscles, as compared to controls; mib2S2616 homozygous and mib2S0768/mib21 transheterozygous late stage 16 embryos present a bloated midgut phenotype, and an irregular arrangement of longitudinal visceral muscle fibers, as compared to controls.

      mib2S1456/mib2S2616 and mib2S1259/mib2S2616 transheterozygotes present a fully (or nearly fully) penetrant flightless phenotype, as compared to controls.

      (Domsch et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mib2S2616
      (Domsch et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)