FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cpxS126A.UAS.7B
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General Information
Symbol
Dmel\cpxS126A.UAS.7B
Species
D. melanogaster
Name
FlyBase ID
FBal0325835
Feature type
allele
Associated gene
Dmel\cpx
Associated Insertion(s)
Carried in Construct
P{UAS-cpx.7B.S126A}
Key Links
Transgenic product class
missense_variant
(Cho et al., 2015)
polypeptide_post_translational_processing_variant
(Cho et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Cho et al., 2015)
polypeptide_post_translational_processing_variant
(Cho et al., 2015)
Mutagen
in vitro construct
(Cho et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-cpx.7B.S126A}
Cytology
Description

UAS regulatory sequence drive expression of cpx isoform 7B with a S126A aa substitution (to mimic phosphoincompetent cpx).

(Cho et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cpx
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rescue cpxSH1 mutant larvae expressing cpxS126A.UAS.7B (with Scer\GAL4elav-C155) fail to display normal enhancement of the frequency of spontaneous releases (mini excitatory junction potentials) after a high-frequency stimulation, and similarly - unlike the controls - do not show temperature-induced synaptic growth (increase in the number of boutons at 29[o]C as compared to larvae reared at 25[o]C).

      (Cho et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      cpxSH1 mutant larvae expressing Mmus\PrkacamC.UAS under the control of Scer\GAL4elav-C155 exhibit synaptic overgrowth (increased number of boutons) at neuromuscular junctions, similar to Mmus\PrkacamC.UAS expression alone, and this is significantly suppressed by co-expression of cpxS126A.UAS.7B.

      (Cho et al., 2015)
      Complementation and Rescue Data
      Partially rescues

      cpxS126A.UAS.7B/Scer\GAL4elav-C155 partially rescues cpxSH1

      (Cho et al., 2015)
      Comments

      Scer\GAL4elav-C155-driven expression of cpxS126A.UAS.7B (phosphoincompetent mutant) efficiently , if not completely, rescues the synaptic overgrowth (increased number of boutons), the increased frequency of spontaneous mini excitatory junction potentials and also suppresses the reduced amplitude of evoked responses at neuromuscular junctions (observed across a range of Ca[2+]) characteristic for cpxSH1 mutant larvae.

      (Cho et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CpxS126A
      (Cho et al., 2015)
      cpxS126A.Scer\UAS.7B
      cpxS126A.UAS.7B
      Name Synonyms
      Secondary FlyBase IDs
        References (1)