FlyBase Allele Report: Dmel\Opa1[UAS.cUa]

General Information

Symbol

Dmel\Opa1^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0326169

Feature type

allele

Associated gene

Dmel\Opa1

Associated Insertion(s)

Carried in Construct

P{UAS-Opa1.U}

Also Known As

UAS-Opa1

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Opa1.U}

Cytology

Description

UAS regulatory sequences drive expression of Opa1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Opa1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TAF15^UAS.cCa

(Altanbyek et al., 2016)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cEa

(Altanbyek et al., 2016)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cUa

(Altanbyek et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

mitochondrion | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

Detailed Description

Statement

Reference

Expression of Opa1^UAS.cUa under the control of Scer\GAL4^VGlut-OK371 significantly reduces mitochondrial number (to zero) in axons of adult neurons, compared to controls.

(Smith et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Opa1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has abnormal neuroanatomy | adult stage phenotype, non-suppressible | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Opa1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has mitochondrion | adult stage phenotype, non-suppressible | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Opa1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has axon | adult stage phenotype, non-suppressible | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Opa1^Scer\UAS.cUa

Opa1^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (7)

Report Sections

Open Close