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General Information
Symbol
Dmel\gfzf541
Species
D. melanogaster
Name
FlyBase ID
FBal0353108
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C7150495T

Amino acid change:

R46term | gfzf-PB; R46term | gfzf-PE

Reported amino acid change:

R46term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R46term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

gfzf541 homozygous mutant MARCM clones of glutamatergic neurons in the wing have significantly increased mitochondrial length and significantly reduced mitochondrial number in their axons, compared to controls, with no effect on total mitochondrial area; mitochondrial morphology is also altered in the cell bodies, compared to controls, and there is a significant reduction in mitochondrial trafficking, but no loss of neurons; alterations in mitochondrial length and number are also seen in axons of cholinergic and dopaminergic neuronal clones; glial clones and neuromuscular junctions of glutamatergic neuronal clones have no alterations in mitochondrial morphology, compared to controls, and there are no differences in lysosomes, endosomes or peroxisomes in axons and cell bodies.

Electroretinograms from aged flies harboring gfzf541 mutant clones show significantly reduced off transients, significantly delayed time to reach half-maximal corneal depolarization and significantly shorter time to fully repolarize, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
NOT Enhanced by
Suppressed by
Statement
Reference

gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Opa1[+]/Opa1s3475

gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Opa1[+]/Opa1s3475

NOT suppressed by
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

gfzf541 mutant neural clones partially suppress the reduced mitochondrial number phenotype, but do not suppress the age-related decline in intact axons of adults expressing MarfUAS.cUa under the control of Scer\GAL4VGlut-OK371.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)