Amino acid replacement: R46term.
C7150495T
R46term | gfzf-PB; R46term | gfzf-PE
R46term
Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.
gfzf541 homozygous mutant MARCM clones of glutamatergic neurons in the wing have significantly increased mitochondrial length and significantly reduced mitochondrial number in their axons, compared to controls, with no effect on total mitochondrial area; mitochondrial morphology is also altered in the cell bodies, compared to controls, and there is a significant reduction in mitochondrial trafficking, but no loss of neurons; alterations in mitochondrial length and number are also seen in axons of cholinergic and dopaminergic neuronal clones; glial clones and neuromuscular junctions of glutamatergic neuronal clones have no alterations in mitochondrial morphology, compared to controls, and there are no differences in lysosomes, endosomes or peroxisomes in axons and cell bodies.
Electroretinograms from aged flies harboring gfzf541 mutant clones show significantly reduced off transients, significantly delayed time to reach half-maximal corneal depolarization and significantly shorter time to fully repolarize, compared to controls.
gfzf541 has lethal - all die during embryonic stage phenotype, non-enhanceable by Scer\GAL4αTub84B.PL/MarfKK105681
gfzf541 has abnormal neuroanatomy | adult stage | somatic clone phenotype, non-enhanceable by Drp1HMC03230/Scer\GAL4VGlut1-OK371
gfzf541 has abnormal neuroanatomy | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4VGlut1-OK371/Trxr1GD9738
gfzf541 has lethal - all die during embryonic stage phenotype, non-enhanceable by MarfUAS.cUa/Scer\GAL4αTub84B.PL
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by GstO1UAS.cKa/Scer\GAL4VGlut1-OK371
gfzf541 has abnormal neurophysiology | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4VGlut1-OK371/MarfKK105681
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Drp1UAS.cDb
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by MarfUAS.cUa/Scer\GAL4VGlut1-OK371
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4VGlut1-OK371/Pink1UAS.cUa
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/MarfHMC03883
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/MarfKK105681
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Opa1VSH330266
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Opa1[+]/Opa1s3475
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Pink15
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Trxr1cyto.UAS/Scer\GAL4VGlut1-OK371
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Trxr1mito.UAS
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/GstS1UASp.cWa
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Prx2VSH330046
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTT1UAS.Tag:HA
gfzf541 has lethal - all die during embryonic stage phenotype, non-suppressible by Scer\GAL4αTub84B.PL/MarfKK105681
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Drp1HMC03230/Scer\GAL4VGlut1-OK371
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Trxr1GD9738
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTT2UAS.Tag:HA
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTO1UAS.Tag:HA
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTO2UAS.Tag:HA
gfzf541 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Hsap\GSTM1UAS.Tag:HA/Scer\GAL4VGlut1-OK371
gfzf541 has lethal - all die during embryonic stage phenotype, non-suppressible by MarfUAS.cUa/Scer\GAL4αTub84B.PL
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of Pink1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of Opa1VSH330266, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of Drp1UAS.cDb, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1cyto.UAS
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1mito.UAS
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1GD9738
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of MarfKK105681, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of abnormal neuroanatomy | adult stage phenotype of MarfHMC03883, Scer\GAL4VGlut1-OK371
gfzf541 is a suppressor | partially | somatic clone of abnormal neuroanatomy | adult stage phenotype of MarfUAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a suppressor | clone of cells of abnormal neuroanatomy | dominant | adult stage phenotype of Pink15
gfzf541 is a suppressor of abnormal neuroanatomy | dominant | adult stage phenotype of Opa1s3475
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Drp1UAS.cDb, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of MarfKK105681, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Opa1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Opa1VSH330266, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Pink1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1cyto.UAS
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1mito.UAS
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1GD9738
gfzf541 is a non-suppressor | somatic clone of abnormal neuroanatomy | adult stage phenotype of MarfHMC03883, Scer\GAL4VGlut1-OK371
gfzf541 has mitochondrion | adult stage | somatic clone phenotype, non-enhanceable by Drp1HMC03230/Scer\GAL4VGlut1-OK371
gfzf541 has axon | adult stage | somatic clone phenotype, non-enhanceable by Drp1HMC03230/Scer\GAL4VGlut1-OK371
gfzf541 has mitochondrion | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4VGlut1-OK371/Trxr1GD9738
gfzf541 has axon | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4VGlut1-OK371/Trxr1GD9738
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTT1UAS.Tag:HA
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTT1UAS.Tag:HA
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by GstO1UAS.cKa/Scer\GAL4VGlut1-OK371
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by GstO1UAS.cKa/Scer\GAL4VGlut1-OK371
gfzf541 has retina | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4VGlut1-OK371/MarfKK105681
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Drp1UAS.cDb
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Drp1UAS.cDb
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible | partially by MarfUAS.cUa/Scer\GAL4VGlut1-OK371
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible | partially by MarfUAS.cUa/Scer\GAL4VGlut1-OK371
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4VGlut1-OK371/Pink1UAS.cUa
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4VGlut1-OK371/Pink1UAS.cUa
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/MarfHMC03883
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/MarfHMC03883
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/MarfKK105681
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/MarfKK105681
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Opa1VSH330266
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Opa1VSH330266
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Opa1[+]/Opa1s3475
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Opa1[+]/Opa1s3475
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible | partially by Pink15
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible | partially by Pink15
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible | partially by Trxr1cyto.UAS/Scer\GAL4VGlut1-OK371
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible | partially by Trxr1cyto.UAS/Scer\GAL4VGlut1-OK371
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Trxr1mito.UAS
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Trxr1mito.UAS
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/GstS1UASp.cWa
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/GstS1UASp.cWa
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Prx2VSH330046
gfzf541 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4VGlut1-OK371/Prx2VSH330046
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTT2UAS.Tag:HA
gfzf541 has axon | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTT2UAS.Tag:HA
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTO1UAS.Tag:HA
gfzf541 has axon | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTO1UAS.Tag:HA
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTO2UAS.Tag:HA
gfzf541 has axon | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Hsap\GSTO2UAS.Tag:HA
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, non-suppressible by Hsap\GSTM1UAS.Tag:HA/Scer\GAL4VGlut1-OK371
gfzf541 has axon | somatic clone | adult stage phenotype, non-suppressible by Hsap\GSTM1UAS.Tag:HA/Scer\GAL4VGlut1-OK371
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, non-suppressible by Drp1HMC03230/Scer\GAL4VGlut1-OK371
gfzf541 has axon | somatic clone | adult stage phenotype, non-suppressible by Drp1HMC03230/Scer\GAL4VGlut1-OK371
gfzf541 has mitochondrion | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Trxr1GD9738
gfzf541 has axon | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4VGlut1-OK371/Trxr1GD9738
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of Drp1UAS.cDb, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of Drp1UAS.cDb, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of Pink1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of Pink1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of Opa1VSH330266, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of Opa1VSH330266, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1cyto.UAS
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1cyto.UAS
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1mito.UAS
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1mito.UAS
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1GD9738
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1GD9738
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of MarfKK105681, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of MarfKK105681, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of mitochondrion | adult stage phenotype of MarfHMC03883, Scer\GAL4VGlut1-OK371
gfzf541 is a non-enhancer | somatic clone of axon | adult stage phenotype of MarfHMC03883, Scer\GAL4VGlut1-OK371
gfzf541 is a suppressor | partially | somatic clone of mitochondrion | adult stage phenotype of MarfUAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a suppressor | partially | somatic clone of axon | adult stage phenotype of MarfUAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a suppressor | clone of cells of mitochondrion | adult stage phenotype of Pink15
gfzf541 is a suppressor | clone of cells of axon | adult stage phenotype of Pink15
gfzf541 is a suppressor of mitochondrion | adult stage phenotype of Opa1s3475
gfzf541 is a suppressor of axon | adult stage phenotype of Opa1s3475
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Drp1UAS.cDb, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Drp1UAS.cDb, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Opa1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Opa1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Opa1VSH330266, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Opa1VSH330266, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Pink1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Pink1UAS.cUa, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1cyto.UAS
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of MarfKK105681, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1cyto.UAS
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1mito.UAS
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1mito.UAS
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1GD9738
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of Scer\GAL4VGlut1-OK371, Trxr1GD9738
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of MarfKK105681, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of mitochondrion | adult stage phenotype of MarfHMC03883, Scer\GAL4VGlut1-OK371
gfzf541 is a non-suppressor | somatic clone of axon | adult stage phenotype of MarfHMC03883, Scer\GAL4VGlut1-OK371
gfzf541 mutant neural clones partially suppress the reduced mitochondrial number phenotype, but do not suppress the age-related decline in intact axons of adults expressing MarfUAS.cUa under the control of Scer\GAL4VGlut-OK371.
gfzf541 is rescued by gfzfUAS.cSa/Scer\GAL4VGlut1-OK371
gfzf541 is rescued by gfzf+tCH322-97B15
gfzf541 is rescued by gfzfUAS.cSa/Scer\GAL4αTub84B.PL
gfzf541 is rescued by Scer\GAL4VGlut1-OK371/gfzfΔN.UAS
gfzf541 is not rescued by Scer\GAL4elav-C155/gfzfUAS.cSa
gfzf541 is not rescued by gfzfΔN.UAS/Scer\GAL4αTub84B.PL
Scer\GAL4VGlut1-OK371/gfzf541 fails to rescue gfzfUAS.cSa