FlyBase Allele Report: Dmel\Trxr1[GD9738]

General Information

Symbol

Dmel\Trxr1^GD9738

Species

D. melanogaster

Name

FlyBase ID

FBal0208855

Feature type

allele

Associated gene

Dmel\Trxr1

Associated Insertion(s)

Carried in Construct

P{GD9738}

Also Known As

UAS-Trxr1^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9738}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9738

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

mitochondrion | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

wing disc posterior compartment, with Scer\GAL4^e22c

(Clemente-Ruiz et al., 2016)

Detailed Description

Statement

Reference

Expression of Trxr-1^GD9738 under the control of Scer\GAL4^VGlut-OK371 significantly reduces mitochondrial number and significantly increases mitochondrial length in axons of adult neurons, compared to controls.

(Smith et al., 2019)

The expression of Trxr-1^GD9738 under the control of Scer\GAL4^e22c leads to increased apoptosis in the wing disc posterior compartment, as compared to controls.

(Clemente-Ruiz et al., 2016)

Expression of Trxr-1^GD9738 under the control of Scer\GAL4^en-e16E results in increased hydrogen peroxide levels and increased glutathione oxidation in both the cytosol and mitochondria in the posterior compartment of the wing disc.

(Albrecht et al., 2011)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

(Neumüller et al., 2011)

Adults expressing Trxr-1^GD9738 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development