FlyBase Allele Report: Dmel\Pink1[UAS.cUa]

General Information

Symbol

Dmel\Pink1^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0319548

Feature type

allele

Associated gene

Dmel\Pink1

Associated Insertion(s)

Carried in Construct

P{UAS-Pink1.U}

Also Known As

UAS-pink1

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

Progenitor genotype

Carried in construct

P{UAS-Pink1.U}

Cytology

Description

UAS regulatory sequences drive expression of Pink1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Pink1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease 6

CEC

(Sanchez-Martinez et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Hao et al., 2010)

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Agnihotri et al., 2016)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Campesan et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^elav.PU

(Zhu et al., 2021)

abnormal neuroanatomy | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

viable, with Scer\GAL4^da.PU

(Hao et al., 2010)

visible | adult stage, with Scer\GAL4^GMR.PF

(Sanchez-Martinez et al., 2023)

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

eye, with Scer\GAL4^GMR.PF

(Sanchez-Martinez et al., 2023)

mitochondrion | adult stage, with Scer\GAL4^VGlut1-OK371

(Smith et al., 2019)

Detailed Description

Statement

Reference

Third instar larvae expressing Pink1^UAS.cUa under the control of Scer\GAL4^elav.PU show a delayed righting reflex.

(Zhu et al., 2021)

Expression of Pink1^UAS.cUa under the control of Scer\GAL4^VGlut-OK371 significantly reduces mitochondrial length in axons of adult neurons, compared to controls, with no effect on mitochondrial number.

(Smith et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-enhanceable by ntc^UAS.cSa, Scer\GAL4^GMR.PF

(Sanchez-Martinez et al., 2023)

Pink1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has abnormal neuroanatomy | adult stage phenotype, non-enhanceable | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

NOT suppressed by

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has abnormal neuroanatomy | adult stage phenotype, non-suppressible | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Enhancer of

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^elav.PU is an enhancer of short lived phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Pink1^UAS.cUa, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Pink1^UAS.cUa, Scer\GAL4^elav.PU is an enhancer of visible | adult stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Suppressor of

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^elav.PU is a suppressor | partially of abnormal locomotor behavior | third instar larval stage phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Scer\GAL4^VGlut1-OK371/Pink1^UAS.cUa is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Other

Statement

Reference

DJ-1α^Δ72, Pink1^UAS.cUa, Scer\GAL4^da.PU, dj-1β^Δ93 has lethal phenotype

(Hao et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by ntc^UAS.cSa, Scer\GAL4^GMR.PF

(Sanchez-Martinez et al., 2023)

Pink1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has mitochondrion | adult stage phenotype, non-enhanceable | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Pink1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has axon | adult stage phenotype, non-enhanceable | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

NOT suppressed by

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has mitochondrion | adult stage phenotype, non-suppressible | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Pink1^UAS.cUa, Scer\GAL4^VGlut1-OK371 has axon | adult stage phenotype, non-suppressible | somatic clone by gfzf⁵⁴¹

(Smith et al., 2019)

Enhancer of

Statement

Reference

Pink1^UAS.cUa, Scer\GAL4^elav.PU is an enhancer of wing phenotype of Hsc70-5^KK100233, Scer\GAL4^elav.PU

(Zhu et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/Pink1^UAS.cUa is a suppressor | partially of mitochondrion | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Scer\GAL4^VGlut1-OK371/Pink1^UAS.cUa is a suppressor | partially of axon | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Pink1^Scer\UAS.cUa under the control of Scer\GAL4^da.PU results in lethality in the DJ-1α^Δ72/DJ-1α^Δ72, dj-1β^Δ93/dj-1β^Δ93 double mutant background.

(Hao et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^da.PU/Pink1^UAS.cUa partially rescues Pink1^B9

(Hao et al., 2010)

Comments

Expression of Pink1^Scer\UAS.cUa under the control of Scer\GAL4^da.PU partially rescues the wing posture defect of Pink1^B9/Pink1^B9 mutants.

(Hao et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pink1^Scer\UAS.cUa

Pink1^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (10)

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