FB2026_02 , released June 18, 2026
Allele: Dmel\knon1400
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General Information
Symbol
Dmel\knon1400
Species
D. melanogaster
Name
FlyBase ID
FBal0326182
Feature type
allele
Associated gene
Dmel\knon
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Sawyer et al., 2017)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        knon1400 males are viable but completely sterile as they have no individualize, motile sperm the Nebenkern fail to elongate beside the growing flagellar axoneme (no mitochondrial derivatives are associated with the axonemes in the elongating spermatid cysts); the internal Nebenkern structure is aberrant but the mitochondria in the testes do have a membrane potential.

        Females are both viable and fertile.

        (Sawyer et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The spermatid mitochondria in knon1400;fzo1 double mutants successfully elongate alongside the axoneme, although the the elongation appears to be slightly delayed.

        (Sawyer et al., 2017)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        knon1400/Df(2R)7E is rescued by knonGFP(mut3star)

        (Sawyer et al., 2017)
        Comments

        The spermatogenesis defect characteristic for knon1400 mutants cannot be complemented by combination with Df(2R)7E but are complemented by Df(2R)BSC550.

        The male sterility as well as the defective mitochondrial shaping and elongation during spermatogenesis observed in knon1400;Df(2R)7E is rescued by combination with knonT:Avic\GFP-mut3star.

        (Sawyer et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Isolated in a screen for mutations generated by mobilisation of a P{lacW} element insertion, however, the knon1400 mutation is not associated with a P{lacW} insertion.

        (Sawyer et al., 2017)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        knon1400
        knonms(2)1400
        (Sawyer et al., 2017)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)