FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Syt1UAS.Tag:MYC
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General Information
Symbol
Dmel\Syt1UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0326194
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
Carried in Construct
P{UAS-Syt1.WT.Myc}
Key Links
Transgenic product class
wild_type
(Herrmann et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Herrmann et al., 2014)
Mutagen
in vitro construct
(Herrmann et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Syt1.WT.Myc}
Cytology
Description

UAS regulatory sequences drive expression of wild-type Syt1 tagged with Tag:MYC.

(Herrmann et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Syt1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Syt1I426K.UAS.Tag:MYC under the control of Scer\GAL4elav-C155 does not induce synaptic transmission defects across the larval neuromuscular junction.

      (Montes-Chinea et al., 2018)

      Ectopic expression of Syt1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 does not induce any neurotransmission defects at third instar larval neuromuscular junctions.

      (Herrmann et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/Syt1UAS.Tag:MYC rescues Syt1AD4/Syt1N13

      (Montes-Chinea et al., 2018)

      Scer\GAL4elav-C155/Syt1UAS.Tag:MYC rescues Syt1unspecified

      (Herrmann et al., 2014)
      Comments

      The neurotransmission defects at neuromuscular junctions in (they fail to support calcium-triggered neurotransmitter release: flat excitatory postsynaptic current, recorded in 2 mM external Ca[2+] with amplitude, reduced cumulative vesicle release (defined by charge transfer), high frequency of miniature excitatory junction currents) characteristic for Syt1unspecified mutant third instar larvae is rescued by Scer\GAL4elav-C155-driven expression of Syt1Scer\UAS.T:Hsap\MYC in the mutant background.

      (Herrmann et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Syt1Scer\UAS.T:Hsap\MYC
      Syt1UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)