FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mettl3SK2
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General Information
Symbol
Dmel\Mettl3SK2
Species
D. melanogaster
Name
FlyBase ID
FBal0327396
Feature type
allele
Associated gene
Dmel\Mettl3
Associated Insertion(s)
Carried in Construct
Also Known As
Ime4sk2
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Wang et al., 2021)

loss of function allele

(Kan et al., 2017)
Mutagen
CRISPR/Cas9
(Kan et al., 2017)
Progenitor genotype
Cytology
Description

A frameshift indel in the second exon (coding region) expected to produce a non-functional protein.

(Kan et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:24,032,578..24,032,580 [+]
Inserted_sequence:

CCGA

Comment:

Replacement of TCG with CCGA in the Mettl3 coding sequence leads to a frameshift after amino acid 106 and early translation termination.

(Kan et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mettl3SK2/Df(3R)Exel6197 adult flies show highly penetrant wing posture defects (held-out wings) and are completely flightless.

      (Guo et al., 2018)

      Mettl3SK2/Df(3R)Exel6197 transheterozygous adults exhibit a "held-out" wing phenotype in the majority of the population and exhibit severe locomotion defects, as shown by the inability to fly and by the decreased climbing capacity (more pronounced in males than in females) in negative geotaxis assays, as compared o controls; females exhibit modest oogenesis defects, as shown by the small decrease and delay in the number and developmental stage of egg chambers, respectively, as compared to controls.

      The progeny from Mettl3SK2/Df(3R)Exel6197 females and control males exhibits a significant increase in the female:male ratio as compared to the progeny from controls.

      (Kan et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Ime4SK2
      Ime4sk2
      (Rockwell and Hongay, 2020)
      Mettl3SK2
      (Wang et al., 2021, Worpenberg et al., 2021)
      Mettl3SK2
      (Guo et al., 2018)
      ime4SK2
      (Kan et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)