FlyBase Allele Report: Dmel\mtd[MI02920-TG4.0]

General Information

Symbol

Dmel\mtd^{MI02920-TG4.0}

Species

D. melanogaster

Name

FlyBase ID

FBal0327710

Feature type

allele

Associated gene

Dmel\mtd

Associated Insertion(s)

Mi{Trojan-GAL4.0}mtd^{MI02920-TG4.0}

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

phiC31 integrase

Nature of the Allele

Allele class

Mutagen

phiC31 integrase

(Gene Disruption Project members, 2016-)

Progenitor genotype

Mi{MIC}mtd^MI02920

(Gene Disruption Project members, 2016-)

Associated Insertion(s)

Mi{Trojan-GAL4.0}mtd^{MI02920-TG4.0}

Cytology

Description

The RMCE cassette of the Mi{MIC}mtd^MI02920 insertion has been replaced with a Trojan-Gal4 cassette. The insertion is in a coding intron of mtd and is predicted to gene trap the gene. (Note that if this gene has multiple transcripts, only those where the insertion is in a coding intron are predicted to be trapped).

(Gene Disruption Project members, 2016-)

Allele components

Component

Use(s)

Inserted element

Mi{Trojan-GAL4.0}

gene trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:5,289,783..5,289,783 [+]

(Wang et al., 2019, Gene Disruption Project members, 2016-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Wang et al., 2019)

abnormal locomotor behavior | adult stage (with Df(3R)3-4)

(Wang et al., 2019)

bang sensitive

(Wang et al., 2019)

bang sensitive (with Df(3R)3-4)

(Wang et al., 2019)

lethal - all die before end of P-stage (with mtd¹)

(Wang et al., 2019)

majority die during pharate adult stage

(Wang et al., 2019)

partially lethal - majority die

(Wang et al., 2019)

partially lethal - majority die (with Df(3R)3-4)

(Wang et al., 2019)

short lived

(Wang et al., 2019)

short lived (with Df(3R)3-4)

(Wang et al., 2019)

some die during pharate adult stage (with Df(3R)3-4)

(Wang et al., 2019)

some die during pupal stage

(Wang et al., 2019)

some die during pupal stage (with Df(3R)3-4)

(Wang et al., 2019)

viable (with mtd^MI02920)

(Wang et al., 2019)

visible | adult stage

(Wang et al., 2019)

visible | adult stage (with Df(3R)3-4)

(Wang et al., 2019)

Phenotype Manifest In

wing

(Wang et al., 2019)

wing (with Df(3R)3-4)

(Wang et al., 2019)

Detailed Description

Statement

Reference

The few surviving mtd^{MI02920-TG4.0} homozygous and mtd^{MI02920-TG4.0}/Df(3R)3-4 transheterozygous adults show decreased climbing ability, as compared to controls. However, histological sections of mtd^{MI02920-TG4.0} adult brains and thorax muscles reveals no obvious defects.

(Wang et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(3R)3-4/mtd^{MI02920-TG4.0} has partially lethal - majority die phenotype, suppressible by Scer\GAL4^{mtd-MI02920-TG4.0}/Hsap\NCOA7^UAS.Tag:HA

(Wang et al., 2019)

Df(3R)3-4/mtd^{MI02920-TG4.0} has partially lethal - majority die phenotype, suppressible by Scer\GAL4^{mtd-MI02920-TG4.0}/Hsap\OXR1^UAS.Tag:HA