FlyBase Allele Report: Hsap\RELA[AD.R14E06]

General Information

Symbol

Hsap\RELA^AD.R14E06

Species

H. sapiens

Name

FlyBase ID

FBal0328379

Feature type

allele

Associated gene

Hsap\RELA

Associated Insertion(s)

Carried in Construct

P{R14E06-p65.AD}

PBac{R14E06-p65.AD}

Also Known As

R14E06

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Rubin Laboratory at Janelia Farm, 2017)

Progenitor genotype

Carried in construct

P{R14E06-p65.AD}

PBac{R14E06-p65.AD}

Cytology

Description

The GMR14E06 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)

Allele components

Component

Use(s)

Regulatory region(s)

GMR14E06

Encoded product / tool

p65(AD)::Zip+

split driver - transcription activation fragment

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval mushroom body dopaminergic neuron g1

Comment: when combined with P{R27G01-GAL4.DBD} (combination referred to as 'SS01716')

(Truman et al., 2023, Eschbach et al., 2020, Saumweber et al., 2018)

larval mushroom body dopaminergic neuron c1

Comment: when combined with P{R53C05-GAL4.DBD} (combination referred to as 'SS01702')

(Eschbach et al., 2020)

larval mushroom body input neuron e2

Comment: when combined with P{R53C05-GAL4.DBD} (combination referred to as 'SS01702')

(Eschbach et al., 2020)

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | larval stage | conditional, with Hsap\KCNJ2^5XUAS.EGFP, Scer\GAL4^DBD.R27G01

(Saumweber et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Inhibition (using Hsap\KCNJ2^5XUAS.EGFP) of neurons targeted by the split-GAL4 pair of Scer\GAL4^DBD.R27G01 and Hsap\RELA^AD.R14E06 in third instar larvae does not significantly affect short-term associative appetitive olfactory memory following training with fructose, innate odor (n-amylacetate) preference or innate fructose preference, compared to controls; olfactory behavior is more susceptible to non-associative effects of odor-only and fructose-only exposure, compared to controls.

(Saumweber et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions