FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\RELAAD.R29G05
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General Information
Symbol
Hsap\RELAAD.R29G05
Species
H. sapiens
Name
FlyBase ID
FBal0328679
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
P{R29G05-p65.AD}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rubin Laboratory at Janelia Farm, 2017)
Progenitor genotype
Carried in construct
P{R29G05-p65.AD}
Cytology
Description

The GMR29G05 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
GMR29G05
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult lateral horn PD2a1 neuron

      Comment: when combined with P{R37G11-GAL4.DBD} (combination referred to as 'LH989')

      when combined with P{R73B12-GAL4.DBD} (combination referred to as 'LH991')

      (Dolan et al., 2019, Dolan et al., 2018)
      adult lateral horn PD2b1 neuron

      Comment: when combined with P{R37G11-GAL4.DBD} (combination referred to as 'LH989')

      when combined with P{R73B12-GAL4.DBD} (combination referred to as 'LH991')

      (Dolan et al., 2019, Dolan et al., 2018)
      neuron of adult ventral nerve cord

      Comment: when combined with P{R73B12-GAL4.DBD} (combination referred to as 'LH991')

      when combined with P{R37G11-GAL4.DBD} (combination referred to as 'LH989')

      (Dolan et al., 2018)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using shi1.UAS at 33[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R37G11 and Hsap\RELAAD.R29G05 in adults during testing significantly impairs immediate, 3-hour and long-term aversive olfactory memory, compared to controls, with no effect on naive avoidance of training odors; this inhibition also significantly reduces innate attraction to apple cider vinegar and ethyl acetate, but not isoamyl acetate, compared to controls.

      (Dolan et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.R29G05.T:Zzzz\Zip+
      Hsap\RELAAD.R29G05
      Name Synonyms
      Secondary FlyBase IDs
        References (10)