FlyBase Allele Report: Hsap\RELA[AD.R42B02]

General Information

Symbol

Hsap\RELA^AD.R42B02

Species

H. sapiens

Name

FlyBase ID

FBal0328855

Feature type

allele

Associated gene

Hsap\RELA

Associated Insertion(s)

Carried in Construct

P{R42B02-p65.AD}

Key Links

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Rubin Laboratory at Janelia Farm, 2017)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{R42B02-p65.AD}

Cytology

Nature of the lesion

Statement

Reference

The GMR42B02 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)

Allele components

Product class / Tool use(s)

Encoded product / tool

p65(AD)::Zip+

split driver - transcription activation fragment

Associated Sequence Features

GMR42B02

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

descending neuron of the gnathal ganglion DNg07

Comment: when combined with P{VT059427-GAL4.DBD} (combination referred to as 'SS02547')

(Namiki et al., 2018)

descending neuron of the gnathal ganglion DNg02

Comment: when combined with P{VT042835-GAL4.DBD} (combination referred to as 'SS02634')

(Namiki et al., 2018)

descending neuron of the gnathal ganglion DNg03

Comment: when combined with P{VT044958-GAL4.DBD} (combination referred to as 'SS02633')

(Namiki et al., 2018)

descending neuron of the gnathal ganglion DNg06

Comment: when combined with P{VT015782-GAL4.DBD} (combination referred to as 'SS01598')

(Namiki et al., 2018)

descending neuron of the gnathal ganglion DNg08

Comment: when combined with P{VT037574-GAL4.DBD} (combination referred to as 'SS02635')

(Namiki et al., 2018)

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal grooming behavior | adult stage | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\GAL4^DBD.VT037574

(Cande et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Acute optogenetic activation (using Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus} with 627 nm (red) light) of neurons targeted by the split-GAL4 pair of Scer\GAL4^DBD.VT037574 and Hsap\RELA^AD.R42B02 significantly induces head grooming behavior, unlike controls.

(Cande et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions