FlyBase Allele Report: Hsap\RELA[AD.VT023490]

General Information

Symbol

Hsap\RELA^AD.VT023490

Species

H. sapiens

Name

FlyBase ID

FBal0330146

Feature type

allele

Associated gene

Hsap\RELA

Associated Insertion(s)

Carried in Construct

P{VT023490-p65.AD}

Also Known As

VT023490-p65ADZp, VT023490-p65.AD

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Rubin Laboratory at Janelia Farm, 2017)

Progenitor genotype

Carried in construct

P{VT023490-p65.AD}

Cytology

Description

The VT023490 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)

Allele components

Component

Use(s)

Regulatory region(s)

VT023490

Encoded product / tool

p65(AD)::Zip+

split driver - transcription activation fragment

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

descending neuron of the posterior brain DNp09

Comment: when combined with P{R38F04-GAL4.DBD} (combination referred to as 'SS01540')

(Namiki et al., 2022, Namiki et al., 2018, Zacarias et al., 2018)

descending neuron of the anterior dorsal brain DNa08

Comment: when combined with P{R80H02-GAL4.DBD} (combination referred to as 'SS02393')

(Namiki et al., 2022, Namiki et al., 2018)

adult brain | faint | restricted

Comment: when combined with P{R38F04-GAL4.DBD} (combination referred to as 'SS01540')

(Zacarias et al., 2018)

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\GAL4^DBD.R38F04

(Cande et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Acute optogenetic activation (using Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus} with 627 nm (red) light) of neurons targeted by the split-GAL4 pair of Scer\GAL4^DBD.R38F04 and Hsap\RELA^AD.VT023490 induces repeated running and pausing behavior, unlike controls.

(Cande et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions