FlyBase Allele Report: Dmel\fry[MI12326-TG4.1]

General Information

Symbol

Dmel\fry^{MI12326-TG4.1}

Species

D. melanogaster

Name

FlyBase ID

FBal0336088

Feature type

allele

Associated gene

Dmel\fry

Associated Insertion(s)

Mi{Trojan-GAL4.1}fry^{MI12326-TG4.1}

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

phiC31 integrase

Nature of the Allele

Allele class

Mutagen

phiC31 integrase

(Gene Disruption Project members, 2016-)

Progenitor genotype

Mi{MIC}fry^MI12326

(Gene Disruption Project members, 2016-)

Associated Insertion(s)

Mi{Trojan-GAL4.1}fry^{MI12326-TG4.1}

Cytology

Description

The RMCE cassette of the Mi{MIC}fry^MI12326 insertion has been replaced with a Trojan-GAL4 cassette. The insertion is in a coding intron of fry and is predicted to gene trap the gene. (Note that if this gene has multiple transcripts, only those where the insertion is in a coding intron are predicted to be trapped).

(Gene Disruption Project members, 2016-)

Allele components

Component

Use(s)

Inserted element

Mi{Trojan-GAL4.1}

gene trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:9,673,365..9,673,372 [-]

(Pan et al., 2024, Marcogliese et al., 2022, Lee et al., 2018, Gene Disruption Project members, 2016-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of syndromic intellectual disability

CEA

(Pan et al., 2024)

CEA with fry^F2746S.PE

(Pan et al., 2024)

CEA with fry^F2746S.RMCE

(Pan et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of syndromic intellectual disability

is ameliorated by fry^F2024L.PE

(Pan et al., 2024)

is ameliorated by fry^F2024L.RMCE

(Pan et al., 2024)

is ameliorated by fry^S2910I.RMCE

(Pan et al., 2024)

is ameliorated by fry^Y3410C.RMCE

(Pan et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)BSC669)

(Lee et al., 2018)

lethal - all die before end of P-stage

(Pan et al., 2024)

lethal - all die before end of second instar larval stage (with Df(3L)BSC669)

(Pan et al., 2024)

lethal - all die before end of second instar larval stage (with fry¹)

(Pan et al., 2024)

lethal - all die before end of second instar larval stage (with fry^F2746S.PE)

(Pan et al., 2024)

lethal - all die before end of second instar larval stage (with fry^F2746S.RMCE)

(Pan et al., 2024)

majority die during first instar larval stage (with Df(3L)BSC669)

(Pan et al., 2024)

majority die during first instar larval stage (with fry^F2746S.RMCE)

(Pan et al., 2024)

majority die during P-stage

(Pan et al., 2024)

some die during embryonic stage (with Df(3L)BSC669)

(Pan et al., 2024)

some die during embryonic stage (with fry¹)

(Pan et al., 2024)

some die during embryonic stage (with fry^F2746S.PE)

(Pan et al., 2024)

some die during embryonic stage (with fry^F2746S.RMCE)

(Pan et al., 2024)

some die during first instar larval stage (with fry¹)

(Pan et al., 2024)

some die during first instar larval stage (with fry^F2746S.PE)

(Pan et al., 2024)

some die during second instar larval stage

(Pan et al., 2024)

some die during second instar larval stage (with Df(3L)BSC669)

(Pan et al., 2024)

some die during second instar larval stage (with fry¹)

(Pan et al., 2024)

some die during second instar larval stage (with fry^F2746S.PE)

(Pan et al., 2024)

some die during second instar larval stage (with fry^F2746S.RMCE)

(Pan et al., 2024)

some die during third instar larval stage

(Pan et al., 2024)

viable (with fry^F2024L.PE)

(Pan et al., 2024)

viable (with fry^F2024L.RMCE)

(Pan et al., 2024)

viable (with fry^S2910I.RMCE)

(Pan et al., 2024)

viable (with fry^WT.RMCE)

(Pan et al., 2024)

viable (with fry^Y3410C.RMCE)

(Pan et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

fry¹

(Pan et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

76736

y¹ w^*; Mi{Trojan-GAL4.1}fry^{MI12326-TG4.1}/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fry^{MI12326-TG4.1}

fry^T2A-GAL4

(Pan et al., 2024)

fry^TG4

(Marcogliese et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections