FlyBase Allele Report: Dmel\PpV[Δ1]

General Information

Symbol

Dmel\PpV^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0336295

Feature type

allele

Associated gene

Dmel\PpV

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Ma et al., 2017)

Mutagen

P-element activity

(Ma et al., 2017)

Progenitor genotype

P{SUPor-P}KG09672

(Ma et al., 2017)

Cytology

Description

Imprecise excision of the progenitor, resulting in deletion of the entire coding region of PpV.

(Ma et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has increased occurrence of cell division | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has neoplasia | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Tak1^K46R.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Enhancer of

Statement

Reference

PpV^Δ1/PpV^Δ1 is an enhancer of neoplasia | third instar larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1/PpV^Δ1 is an enhancer of increased occurrence of cell division | third instar larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV[+], fmt[+], PpV^Δ1, fmt¹ is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

PpV[+]/PpV^Δ1 is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

PpV[+]/PpV^Δ1 is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

PpV[+], fmt[+], PpV^Δ1, fmt¹ is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by bsk^DN.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV^Δ1, Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C has eye-antennal disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by Tak1^K46R.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

Enhancer of

Statement

Reference

PpV[+], fmt[+], PpV^Δ1, fmt¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

PpV^Δ1/PpV^Δ1 is an enhancer of eye-antennal disc | third instar larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C

(Ma et al., 2017)

PpV[+]/PpV^Δ1 is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cIa

(Ma et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The tumorigenicity of Scer\GAL4^{Scer\FRT.Act5C}>Ras85D^V12.Scer\UAS-expressing clones in third instar larval eye-antennal discs is enhanced if the clones are also mutant for PpV^Δ1, they display invasive behavior and increased mitotic activity; these characteristics are suppressed by co-expression of bsk^DN.Scer\UAS or Tak1^{K46R.Scer\UAS}.

The small rough eye phenotype characteristic for adult flies expressing egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PU is enhanced by combination with a single copy of PpV^Δ1 or fmt¹, when combined with one copy of both fmt¹ and PpV^Δ1 the eye is almost completely lost.

(Ma et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

82142

y¹ PpV^Δ1 P{neoFRT}19A/FM6

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PpV^Δ1

(Ma et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close