FlyBase Allele Report: Dmel\sotv[GD2025]

General Information

Symbol

Dmel\sotv^GD2025

Species

D. melanogaster

Name

FlyBase ID

FBal0336319

Feature type

allele

Associated gene

Dmel\sotv

Associated Insertion(s)

Carried in Construct

P{GD2025}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Poe et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Poe et al., 2017)

Mutagen

in vitro construct

(Poe et al., 2017)

Progenitor genotype

Carried in construct

P{GD2025}

Cytology

Description

UASt regulatory sequences drive expression of and RNAi line that targets sotv.

(Poe et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2025

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with Scer\GAL4^A58

(Poe et al., 2017)

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of sotv^GD2025 under the control of either Scer\GAL4^A58 or Scer\GAL4^hh-Gal4 results in severe reduction in the overall dendrite or terminal dendrite density as well as terminal dendrite number within the intersegmental area in the adjacent class IV dendritic arborizing neurons in third instar larvae.

(Poe et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^A58, sotv^GD2025 has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Enhancer of

Statement

Reference

sotv^GD2025/Scer\GAL4^A58 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A58, sotv^GD2025 has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Scer\GAL4^A58, sotv^GD2025 has dendritic tree | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Scer\GAL4^A58, sotv^GD2025 has distal dendrite | third instar larval stage | cell non-autonomous phenotype, enhanceable by Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Enhancer of

Statement

Reference

sotv^GD2025/Scer\GAL4^A58 is an enhancer of larval multidendritic class IV neuron | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

sotv^GD2025/Scer\GAL4^A58 is an enhancer of dendritic tree | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

sotv^GD2025/Scer\GAL4^A58 is an enhancer of distal dendrite | third instar larval stage phenotype of Ptp69D^CRISPR.14/Df(3L)8ex34

(Poe et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased terminal dendrite density and number in class IV dendritic arborizing neurons observed in third instar larvae either expressing sotv^GD2025 (with the Scer\GAL4^A58 driver) or transheterozygous for Ptp69D^CRISPR.14/Df(3L)8ex34 is further enhanced in the double mutants (Scer\GAL4^A58>sotv^GD2025;Ptp69D^CRISPR.14/Df(3L)8ex34).

(Poe et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v4903

w¹¹¹⁸; P{GD2025}v4903

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ext2^GD2025

sotv^GD2025

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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