FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\KaiR1DQ604R.UAS
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General Information
Symbol
Dmel\KaiR1DQ604R.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0336607
Feature type
allele
Associated gene
Dmel\KaiR1D
Associated Insertion(s)
Carried in Construct
PBac{UAS-KaiR1D.Q604R}
Key Links
Transgenic product class
missense_variant
(Kiragasi et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kiragasi et al., 2017)
Mutagen
in vitro construct
(Kiragasi et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-KaiR1D.Q604R}
Cytology
Description

UAS regulatory sequences drive expression of the KaiR1D ORF (EST RE06730) with a mutation (Q604R) to render the channel calcium impermeable.

(Kiragasi et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
KaiR1D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      KaiR1DQ604R.UAS/Scer\GAL4RapGAP1-OK6 fails to rescue KaiR1DMB01010

      (Kiragasi et al., 2017)
      Comments

      The expression of KaiR1DQ604R.Scer\UAS under the control of Scer\GAL4RapGAP1-OK6 fails to rescue the decreased evoked excitatory postsynaptic potentials and quantal contents under 0.2mM extracellular Ca[2+] concentration conditions observed at KaiR1DMB01010-homozygous larval neuromuscular junctions.

      (Kiragasi et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      KaiR1DQ604R.Scer\UAS
      KaiR1DQ604R.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)