FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ProsapUAS.Tag:MYC
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General Information
Symbol
Dmel\ProsapUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0336722
Feature type
allele
Associated gene
Dmel\Prosap
Associated Insertion(s)
Carried in Construct
P{UAS-Myc.Shank}
Key Links
Transgenic product class
wild_type
(Wu et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2017)
Mutagen
in vitro construct
(Wu et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Myc.Shank}
Cytology
Description

UASt regulates expression of the full-length coding sequence of Shank (GenBank AAF58298.3) tagged with Tag:MYC.

(Wu et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Prosap
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/ProsapUAS.Tag:MYC rescues Prosap8k

      (Wu et al., 2017)

      Scer\GAL4elav.Switch.PO/ProsapUAS.Tag:MYC rescues Prosap8k

      (Wu et al., 2017)
      Partially rescues

      ProsapUAS.Tag:MYC/Scer\GAL4GH146 partially rescues Prosap8k

      (Wu et al., 2017)

      Scer\GAL4Mef2.247, ProsapUAS.Tag:MYC, Scer\GAL4GH146 partially rescues Prosap8k

      (Wu et al., 2017)
      Fails to rescue

      Scer\GAL4Mef2.247/ProsapUAS.Tag:MYC fails to rescue Prosap8k

      (Wu et al., 2017)
      Comments

      The larval mushroom body calyx glomerulus defects observed in Prosap8k-homozygotes (i.e. smaller size, uni-lobed, and decreased number of antennal lobe projection neuron presynaptic bouton protrusions) are rescued by the expression of ProsapScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PU alone (fully), Scer\GAL4elav.Switch.PO in combination with a 3 day RU486 treatment during the larval stage (fully), Scer\GAL4GH146 in combination with Scer\GAL4Mef2.247 (almost fully), or Scer\GAL4GH146 alone (partially), but not Scer\GAL4Mef2.247 alone. The similar adult mushroom body calyx glomerulus defects of these mutants are also rescued by the expression of ProsapScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PU alone.

      (Wu et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ProsapScer\UAS.T:Hsap\MYC
      ProsapUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)