FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lexAGMR48B04
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General Information
Symbol
Ecol\lexAGMR48B04
Species
E. coli
Name
FlyBase ID
FBal0337160
Feature type
allele
Associated gene
Ecol\lexA
Associated Insertion(s)
Carried in Construct
P{GMR48B04-lexA}
Also Known As
R48B04-LexA
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lin et al., 2014)
Progenitor genotype
Carried in construct
P{GMR48B04-lexA}
Cytology
Description

The GMR48B04 fragment is fused upstream of a Drosophila synthetic core promoter (DSCP) followed by sequence encoding a lexA::p65 driver.

(Lin et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
GMR48B04
Encoded product / tool
lexA::p65
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult dopaminergic PAM neuron
      (Owald et al., 2015)
      mushroom body gamma lobe slice 1
      (Huetteroth et al., 2015)
      mushroom body gamma lobe slice 2
      (Huetteroth et al., 2015)
      mushroom body gamma lobe slice 4
      (Huetteroth et al., 2015, Lin et al., 2014)
      mushroom body gamma lobe slice 5
      (Huetteroth et al., 2015, Lin et al., 2014)
      mushroom body beta' lobe slice 2
      (Huetteroth et al., 2015, Lin et al., 2014)
      adult brain | restricted
      (Huetteroth et al., 2015, Lin et al., 2014)
      dopaminergic PAM neuron 1
      (Huetteroth et al., 2015, Lin et al., 2014)
      dopaminergic PAM neuron 2
      (Huetteroth et al., 2015, Lin et al., 2014)
      dopaminergic PAM neuron 6
      (Huetteroth et al., 2015, Lin et al., 2014)
      dopaminergic PAM neuron 5
      (Huetteroth et al., 2015, Lin et al., 2014)
      TH negative neuron associated with PAM cluster
      (Huetteroth et al., 2015)
      dopaminergic neuron | subset
      (Huetteroth et al., 2015)
      adult dopaminergic PAM neuron | subset
      (Lin et al., 2014)
      dopaminergic PAM neuron 8
      (Lin et al., 2014)
      Additional Information
      Statement
      Reference

      EcollexAGMR48B04 positive dopaminergic PAM neurons are in close proximity with ScerGAL4VT001211 expressing mushroom body medial lobe arborizing neurons 4 and 6 as shown by a positive GFP reconstitution across synaptic partners (GRASP) signal.

      (Owald et al., 2015)

      EcollexAGMR48B04 drives expression in PAM neurons, including dopaminergic PAM neurons in mushroom body beta' lobe slice 2 that also show expression driven by ScerGAL4LpR1-0104-G4.

      (Lin et al., 2014)
       
      Marker for
      Reflects expression of
      Oamb
      (Lin et al., 2014)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Blocking the output (using shits.lexAop.cLa at 33[o]C) of a subset (restricted using Scer\GAL4LpR1-0104-G4 and Ecol\lexAdsRNA.UAS.cWa, to remove expression from Scer\GAL4LpR1-0104-G4 neurons) of Ecol\lexAGMR48B04 neurons shortly before and during training significantly impairs short term memory in starved flies trained with arabinose, compared to controls.

      (Huetteroth et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ecol\lexAGMR48B04
      Name Synonyms
      Secondary FlyBase IDs
        References (4)