FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\STUB1UAS.cCa
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General Information
Symbol
Dmel\STUB1UAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Chen
FlyBase ID
FBal0337735
Feature type
allele
Associated gene
Dmel\STUB1
Associated Insertion(s)
Carried in Construct
P{UAS-STUB1.C}
Key Links
Transgenic product class
wild_type
(Chen et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chen et al., 2017)
Mutagen
in vitro construct
(Chen et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-STUB1.C}
Cytology
Description

UAS regulatory sequences drive expression of wild-type STUB1.

(Chen et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
STUB1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Chen et al., 2017)
      modeled by park1, parkΔ21
      (Chen et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      STUB1UAS.cCa/Scer\GAL4Mhc.PU is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of parkΔ21/park1

      (Chen et al., 2017)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The aberrant wing posture, thoracic indentations along with mitochondrial defects (loss of cristae) in indirect flight muscles observed in park1/parkΔ21 transheterozygous adults are all significantly rescued by Scer\GAL4Mhc.PU-driven expression of STUB1Scer\UAS.cCa, whereas their climbing ability deficit is not improved.

      The abnormal wing posture, thoracic indentations, climbing and flight deficit along with severe muscle fiber disorganization and aberrant mitochondrial morphology in the indirect flight muscles characteristic for Pink1B9 mutant adults are all strongly (or fully) suppressed by Scer\GAL4Mhc.PU-driven expression of STUB1Scer\UAS.cCa. Similarly, expression of STUB1Scer\UAS.cCa if driven by Scer\GAL4ple.PU rescues the loss of dorsolateral 1 dopaminergic neurons (da) as well as the mitochondrial aggregation frequently observed in PPL1 da neurons in Pink1B9 adult brains.

      (Chen et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      STUB1UAS.cCa/Scer\GAL4Mhc.PU rescues STUB1I

      (Chen et al., 2017)
      Comments

      The reduced climbing ability of STUB1I mutant adults is rescued by Scer\GAL4Mhc.PU-driven expression of STUB1Scer\UAS.cCa.

      (Chen et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      STUB1Scer\UAS.cCa
      STUB1UAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Chen
      Secondary FlyBase IDs
        References (1)