Blocking synaptic transmission (using shi^1.Scer\UAS at restrictive temperatures) from Scer\GAL4⁰⁷⁷⁰ neurons significantly impairs sucrose-reinforced appetitive memory performance (at 3 or 24 hours since training) compared to controls. Blocking synaptic transmission from Scer\GAL4⁰⁷⁷⁰ neurons significantly impairs electric-shock-reinforced aversive memory performance (at 3hrs) compared to controls. Blocking synaptic transmission from Scer\GAL4⁰⁷⁷⁰ neurons significantly impairs memory (tested 30min after conditioning) in a differential aversive conditioning paradigm (in both the Y[[60]] vs Z[[30]] relative condition and the X[[0]] vs Y[[60]] absolute condition). Flies undergo conditioning at a permissive temperature (23[o]C), whereas testing is at a restrictive temperature (33[o]C); there are no significant memory differences when training and testing is at permissive temperatures. Scer\GAL4⁰⁷⁷⁰>shi^1.Scer\UAS flies exhibit normal olfactory acuity at the restrictive temperature.