FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zldZnF2
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General Information
Symbol
Dmel\zldZnF2
Species
D. melanogaster
Name
FlyBase ID
FBal0337845
Feature type
allele
Associated gene
Dmel\zld
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Hamm et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement: C554S.

(Hamm et al., 2017)

Point mutation within Zinc Finger 2.

(Hamm et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:19,780,626..19,780,626 [-]
Nucleotide change:

G19780626C

Reported nucleotide change:

G?C

Amino acid change:

C554S | zld-PA; C554S | zld-PB; C554S | zld-PD; C554S | zld-PF; C554S | zld-PG

Reported amino acid change:

C554S

Comment:

Missense mutation. There are also two silent substitutions.

(Hamm et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      zldZnF2 homozygous females and hemizygous males are viable albeit at strongly reduced levels but the females are sterile and lay fertilized embryos that arrest late in embryogenesis during stage 17 after tracheal branches have clearly formed. Some (~18%) zldZnF2 mutant adults have small, malformed eye.

      zld294/zldZnF2 females are nearly completely lethal.

      (Hamm et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      zldZnF2
      (Hamm et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)