FlyBase Allele Report: Dmel\Mitofilin[UAS.Tag:MYC]

General Information

Symbol

Dmel\Mitofilin^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0337880

Feature type

allele

Associated gene

Dmel\Mitofilin

Associated Insertion(s)

Carried in Construct

P{UAS-Mitofilin.Myc}

Key Links

Transgenic product class

cDNA

(Tsai et al., 2017)

wild_type

(Tsai et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Tsai et al., 2017)

wild_type

(Tsai et al., 2017)

Mutagen

in vitro construct

(Tsai et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-Mitofilin.Myc}

Cytology

Description

UAS regulatory sequences drive expression of Mitofilin cDNA clone GH04666. The open reading frame is tagged at the C-terminal end with Tag:MYC.

(Tsai et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mitofilin

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Tsai et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Mitofilin^UAS.Tag:MYC, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of abnormal locomotor behavior phenotype of Pink1^B9

(Tsai et al., 2018)

NOT Suppressor of

Statement

Reference

Mitofilin^UAS.Tag:MYC, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a non-suppressor of abnormal locomotor behavior | larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Mitofilin^UAS.Tag:MYC, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Pink1^B9

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of mitochondrion | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of mitochondrial crista | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of mitochondrion | adult stage | progressive phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of mitochondrial crista | adult stage | progressive phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC is a suppressor of indirect flight muscle cell | progressive phenotype of Pink1⁵

(Tsai et al., 2018)

NOT Suppressor of

Statement

Reference

Mitofilin^UAS.Tag:MYC, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Mitofilin^UAS.Tag:MYC/Scer\GAL4^Tub.PU rescues Mitofilin^LL02849

(Tsai et al., 2018)

Scer\GAL4^Act.PU/Mitofilin^UAS.Tag:MYC rescues Mitofilin^LL02849

(Tsai et al., 2017)

Partially rescues

Mitofilin^UAS.Tag:MYC/Scer\GAL4^Tub.PU partially rescues Mitofilin^LL02849

(Tsai et al., 2017)

Scer\GAL4^elav.PU/Mitofilin^UAS.Tag:MYC partially rescues Mitofilin^LL02849

(Tsai et al., 2017)

Comments

The expression of Mitofilin^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Act.PU rescues the lethality of Mitofilin^LL02849 homozygotes; the expression under the control of Scer\GAL4^tub.PU ameliorates the impaired larval crawling ability displayed by Mitofilin^LL02849 homozygotes; the expression under the control of Scer\GAL4^elav.PU ameliorates the decreased mitochondrial membrane potential (assessed by tetramethylrhodamine) at the third instar larval neuromuscular junction synaptic boutons of Mitofilin^LL02849 homozygotes.

(Tsai et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mitofilin^{Scer\UAS.T:Hsap\MYC}

Mitofilin^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close