FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PolQpol-dead
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General Information
Symbol
Dmel\PolQpol-dead
Species
D. melanogaster
Name
FlyBase ID
FBal0337902
Feature type
allele
Associated gene
Dmel\PolQ
Associated Insertion(s)
Carried in Construct
M{PolQ.pol-dead}
Key Links
Transgenic product class
missense_variant
(Beagan et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Beagan et al., 2017)
Mutagen
in vitro construct
(Beagan et al., 2017)
Progenitor genotype
Carried in construct
M{PolQ.pol-dead}
Cytology
Description

A genomic fragment that includes the mus308 transcription unit plus 1.25kb of upstream sequence. The coding region has been mutated to produce a polymerase-dead form of mus308 (amino acid replacements D1826A and F1827A).

(Beagan et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
PolQ
Encoded product / tool
PolQ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The hypersensitivity of Df(3R)mus308Δ/Df(3R)mus308Δ;spn-A3/spn-A093A double mutant third instar larvae to ionizing radiation is not rescued by combination with mus308pol-dead.

      Similarly, the Df(3R)mus308Δ/Df(3R)mus308Δ;spn-A3/spn-A093A mutants show a significant reduction in the frequency of end joining repair events in a P{hsw[a]}-excision repair assay and this also cannot be rescued mus308pol-dead.

      (Beagan et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DNApol-θpol-dead
      PolQpol-dead
      mus308pol-dead
      Name Synonyms
      Secondary FlyBase IDs
        References (1)