FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fic30C
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General Information
Symbol
Dmel\Fic30C
Species
D. melanogaster
Name
FlyBase ID
FBal0337972
Feature type
allele
Associated gene
Dmel\Fic
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Casey et al., 2017)
Mutagen
CRISPR/Cas9
(Casey et al., 2017)
Progenitor genotype
Cytology
Description

101bp deletion that results in a frameshift and an early stop codon after Leu155 of the Fic coding sequence.

(Casey et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia
      CEA
      (Lobato et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fic30C homozygosity alone or in combination with the expression of either FicScer\UAS.T:SV5\V5.T:Zzzz\His6 or FicH375A.Scer\UAS.T:SV5\V5.T:Zzzz\His6 under the control of Scer\GAL4da.G32 is viable and adults have no externally visible phenotypes; Fic30C homozygosity in combination with the expression of FicE247G.Scer\UAS.T:SV5\V5.T:Zzzz\His6 under the control of Scer\GAL4da.G32 is lethal.

      Fic30C homozygotes that also express FicE247G.Scer\UAS.T:SV5\V5.T:Zzzz\His6 alone under the control of Scer\GAL4GMR.long display a severe rough eye phenotype, whereas those that also express FicE247G.I271D.Scer\UAS.T:SV5\V5.T:Zzzz\His6 under the control of Scer\GAL4GMR.long are lethal.

      Fic30C homozygous third instar larval eye discs expressing FicE247G.Scer\UAS.T:SV5\V5.T:Zzzz\His6, but not FicScer\UAS.T:SV5\V5.T:Zzzz\His6, under the control of Scer\GAL4GMR.long show a strong increase in apoptosis in the third instar larval eye disc, as compared to Fic30C homozygotes or to wild-type individuals.

      (Casey et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Fic30C homozygotes expressing FicE247G.Scer\UAS.T:SV5\V5.T:Zzzz\His6 under the control of Scer\GAL4GMR.long exhibit a small and rough eye phenotype, which is rescued by the co-expression of FicScer\UAS.T:SV5\V5.T:Zzzz\His6 or FicI271D.Scer\UAS.T:SV5\V5.T:Zzzz\His6, but not FicH375A.Scer\UAS.T:SV5\V5.T:Zzzz\His6.

      (Casey et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fic30C
      (Lobato et al., 2024)
      fic30C
      (Moehlman et al., 2018, Casey et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)