FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\kek6UAS.mRFP(Unk)
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General Information
Symbol
Dmel\kek6UAS.mRFP(Unk)
Species
D. melanogaster
Name
FlyBase ID
FBal0338017
Feature type
allele
Associated gene
Dmel\kek6
Associated Insertion(s)
Carried in Construct
P{UAS-kek6.mRFP}
Key Links
Transgenic product class
wild_type
(Ulian-Benitez et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ulian-Benitez et al., 2017)
Mutagen
in vitro construct
(Ulian-Benitez et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-kek6.mRFP}
Cytology
Description

UAS regulatory sequences drive expression of kek6 tagged with mRFP(Unk).

(Ulian-Benitez et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
kek6
Tagged with
mRFP(Unk)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of kek6UAS.mRFP(Unk) under the control of Scer\GAL4elav.PU leads to defective larval NMJ targeting, including loss of projections and misrouting/mistargeting, as compared to controls. Expression under the control of Scer\GAL4Toll-6-D42 leads to larval NMJ defects, namely significant increases in the number of branches and of active zones, but not in axonal length or in the number of type Ib boutons, as compared to controls.

      (Ulian-Benitez et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of kek6UAS.mRFP(Unk) under the control of Scer\GAL4elav.PU rescues the lethality of NT141, spz5e03444 double homozygotes to near full viability.

      The expression of kek6UAS.mRFP(Unk) under the control of Scer\GAL4Toll-6-D42 suppresses the NMJ defects of Toll-6MI02127/Df(3L)BSC578 transheterozygotes (i.e. decreases in the number of type Ib boutons, in the axonal length, in the number of NMJ branch points and in the number of active zones); this expression also suppresses the decreases in type I bouton number and in axon length observed at the larval neuromuscular junction of both spz537/Df(3L)Exel6092 single transheterozygotes and of kek634/Df(3R)ED6361, spz537/Df(3L)Exel6092 double transheterozygotes.

      (Ulian-Benitez et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      kek6UAS.mRFP(Unk)/Scer\GAL4Toll-6-D42 partially rescues kek634/Df(3R)ED6361

      (Ulian-Benitez et al., 2017)
      Comments

      The expression of kek6UAS.mRFP(Unk) under the control of Scer\GAL4Toll-6-D42 partially rescues the decreases in type Ib bouton number and axonal length, but not the small increase in the number of ghost boutons, observed at the larval NMJ of kek634/Df(3R)ED6361 transheterozygotes.

      (Ulian-Benitez et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kek6Scer\UAS.T:Disc\RFP-mRFP
      kek6UAS.mRFP(Unk)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)