FB2026_02 , released June 18, 2026
Allele: Dmel\aqz+tCH322-25015
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General Information
Symbol
Dmel\aqz+tCH322-25015
Species
D. melanogaster
Name
FlyBase ID
FBal0340388
Feature type
allele
Associated gene
Dmel\aqz
Associated Insertion(s)
Carried in Construct
PBac{CH322-25015}
Key Links
Transgenic product class
genomic_DNA
(Mendoza-Ortíz et al., 2018)
wild_type
(Mendoza-Ortíz et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Mendoza-Ortíz et al., 2018)
wild_type
(Mendoza-Ortíz et al., 2018)
Mutagen
in vitro construct
(Mendoza-Ortíz et al., 2018)
Progenitor genotype
Carried in construct
PBac{CH322-25015}
Cytology
Description

A genomic BAC (#CH322-25015) comprising 19,384 bp genomic DNA (from 4,631,615 to 4,650,999 on chromosome 3), roughly centered on aqz and encompassing the whole aqzlocus, but also including four other neighboring genes (IscU, CG8369, CG9837, and hng2) and lncRNA:CR43130, that partially overlaps the aqz sequence in the opposite orientation.

(Mendoza-Ortíz et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
aqz
Encoded product / tool
aqz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      aqz+tCH322-25015 homozygous embryos show prevalent central nervous system defects, as compared to controls.

      (Mendoza-Ortíz et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      aqz+tCH322-25015 partially rescues aqz1

      (Mendoza-Ortíz et al., 2018)

      aqz+tCH322-25015 partially rescues aqzCB03335

      (Mendoza-Ortíz et al., 2018)
      Comments

      The embryonic central nervous system defects observed in aqzCB03335 and aqz1 homozygotes are partially rescued by one copy of aqz+tCH322-25015; the lethality of aqzCB03335 is rescued by one copy of aqz+tCH322-25015, but exacerbated by two copies of aqz+tCH322-25015, whereas the lethality of aqz1 is exacerbated by either one or two copies of aqz+tCH322-25015.

      (Mendoza-Ortíz et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      aqz+tCH322-25015
      Name Synonyms
      Secondary FlyBase IDs
        References (1)