FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DAAMRNAi.UAS.FH2
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General Information
Symbol
Dmel\DAAMRNAi.UAS.FH2
Species
D. melanogaster
Name
FlyBase ID
FBal0341187
Feature type
allele
Associated gene
Dmel\DAAM
Associated Insertion(s)
Carried in Construct
P{UAS-DAAM.RNAi.FH2}
Key Links
Transgenic product class
RNAi_reagent
(Migh et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Migh et al., 2018)
Mutagen
in vitro construct
(Migh et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-DAAM.RNAi.FH2}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat against DAAM (FH2 domain) (pVALIUM20 vector).

(Migh et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
DAAM
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of DAAMdsRNA.UAS.FH2 under the control of Scer\GAL4elav-C155 alone or under the combined control of Scer\GAL4elav-C155 and Scer\GAL4Mef2.PR, but not under the control of Scer\GAL4Mef2.PR, leads to larval muscle 4 neuromuscular junction displaying fragmented/absent presynaptic microtubules bundles, a significant decrease in the number of synaptic boutons and 'bouton fusion', as compared to controls.

      (Migh et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DAAMRNAi.UAS.FH2
      DAAMdsRNA.UAS.FH2
      Name Synonyms
      Secondary FlyBase IDs
        References (3)