FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RetLM2
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General Information
Symbol
Dmel\RetLM2
Species
D. melanogaster
Name
FlyBase ID
FBal0341716
Feature type
allele
Associated gene
Dmel\Ret
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Myers et al., 2018)
Mutagen
CRISPR/Cas9
(Myers et al., 2018)
Progenitor genotype
Cytology
Description

18bp in-frame deletion at or very close to the calcium binding site at the start of the cadherin like domain.

(Myers and Kidd, 2019.3.22)

In frame deletion that deletes 6 amino acids in Ret (including a conserved tyrosine residue).

(Myers et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:21,185,940..21,185,957 [-]
Comment:

RetLM2 is an in-frame 18 base pair deletion in Ret at or very close to the calcium binding site at the start of the cadherin like domain.

(Myers and Kidd, 2019.3.22)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Hirschsprung's disease
      CEA
      (Myers et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RetLM2 homozygous larvae, RetLM2/RetLM1 and RetLM2/RetLM3 transheterozygous larvae hatch normally hatch normally but show a range of feeding defects, as compared to controls: a foraging phenotype in which larvae move away from a central food source; accumulation of food in the oesophagus; reduced/absence of food in the midguts and absence of food in the oesophagus. RetLM1 homozygous larvae are frequently immobile or sluggish in response to touch, as compared to controls.

      (Myers et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LM2
      (Myers and Kidd, 2019.3.22)
      RetLM2
      (Myers et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)