FlyBase Allele Report: Dmel\Vps33B[5.20]

General Information

Symbol

Dmel\Vps33B^5.20

Species

D. melanogaster

Name

FlyBase ID

FBal0342445

Feature type

allele

Associated gene

Dmel\Vps33B

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Akbar et al., 2016)

Mutagen

P-element activity

(Akbar et al., 2016)

Progenitor genotype

P{GT1}BG00683

(Akbar et al., 2016)

Caused by aberration

Df(3R)Vps33B^5.20

Cytology

Description

A 2.3 kb-deletion that removes 1161 bp of the Vps33B gene including the first three exons and part of the fourth exon, a total 736bp (the first 196 amino acids) of Vps33B coding sequences. (1,073 bp in the upstream non-coding region at the 5' end of the neighboring Fur1 gene is also deleted.)

(Akbar et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of ARC syndrome

CEA

(Akbar et al., 2016)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Akbar et al., 2016)

fertile

(Akbar et al., 2016)

short lived | conditional

(Akbar et al., 2016)

viable

(Akbar et al., 2016)

Phenotype Manifest In

hemocyte

(Akbar et al., 2016)

wing

(Akbar et al., 2016)

Detailed Description

Statement

Reference

Vps33B^5.20 homozygotes show a 'blemished wing' phenotype. Upon infection, adults display a significant decrease in lifespan and their hemocytes, although able to phagocyte heat-killed E.coli bacteria, are unable to clear them, as compared to infected controls.

(Akbar et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Vps33B^5.20 has short lived | conditional phenotype, suppressible | partially by PGRP-LC^RNAi.UAS.cAa/Scer\GAL4^da.PU

(Akbar et al., 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Vps33B^5.20 is partially rescued by Vps33B^{+tCH322-65H17}

(Akbar et al., 2016)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Vps33B^5.20

(Akbar et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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