FlyBase Allele Report: Dmel\Ret[TKΔ.UAS.Tag:V5]

General Information

Symbol

Dmel\Ret^{TKΔ.UAS.Tag:V5}

Species

D. melanogaster

Name

FlyBase ID

FBal0343411

Feature type

allele

Associated gene

Dmel\Ret

Associated Insertion(s)

Carried in Construct

P{UAS-Ret.TKΔ.V5}

Key Links

Transgenic product class

inframe_deletion

(Hoyer et al., 2018)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Hoyer et al., 2018)

Mutagen

in vitro construct

(Hoyer et al., 2018)

Progenitor genotype

Carried in construct

P{UAS-Ret.TKΔ.V5}

Cytology

Description

UASt regulatory sequences drive expression of an internally deleted form of Ret that lacks the tyrosine kinase domain. The protein is tagged at the C-terminal end with Tag:V5.

(Hoyer et al., 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ret

Tagged with

Tag:V5

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^21-7

(Hoyer et al., 2018)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

Phenotype Manifest In

dendritic tree | third instar larval stage, with Scer\GAL4^21-7

(Hoyer et al., 2018)

dendritic tree | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^21-7

(Hoyer et al., 2018)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^en-e16E

(Hoyer et al., 2018)

Detailed Description

Statement

Reference

Expression of Ret^{TKΔ.UAS.Tag:V5} under the control of Scer\GAL4^en-e16E or Scer\GAL4^21-7, but not Scer\GAL4^ppk.PG, impaired the C4da neuron dendrites, as compared to controls.

(Hoyer et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Ret^{TKΔ.UAS.Tag:V5}/Scer\GAL4^ppk.PG partially rescues Df(2L)BSC312/Ret^ko

(Hoyer et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ret^{TKΔ.UAS.Tag:V5}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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