FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\VAChT-Q.UAS
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General Information
Symbol
Dmel\VAChT-Q.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0343448
Feature type
allele
Associated gene
Dmel\VAChT
Associated Insertion(s)
Carried in Construct
P{UAS-VAChT.-Q}
Key Links
Transgenic product class
inframe_deletion
(Cash et al., 2016)
polymorphic_sequence_variant
(Cash et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Cash et al., 2016)
polymorphic_sequence_variant
(Cash et al., 2016)
Mutagen
in vitro construct
(Cash et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-VAChT.-Q}
Cytology
Description

UAS regulatory sequences drive expression of VAChT in which one Gln residue (at position 549) in the C-terminal polyQ domain has been deleted (this form of VAChT exists as a naturally occurring polymorphism).

(Cash et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
VAChT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of VAChT-Q.UAS under the control of Scer\GAL4ChAT.7.4 in third instar larval aCC/RP2 motoneurons leads to a significant increase in amplitude and frequency of spontaneous mEPSCs compared to controls.

      Expression of VAChT-Q.UAS under the control of Scer\GAL4ChAT.7.4 in third instar larval aCC/RP2 motoneurons leads to evoked spontaneous rhythmic currents (SRCs) with significantly increased duration and significantly reduced frequency compared to controls.

      (Vernon et al., 2019)

      Expression of VAChT-Q.UAS under the control of Scer\GAL4ChAT.7.4 leads to a significant reduction in 5-Cl-CASPP toxicity (reduced mortality) compared to controls.

      (Vernon et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of VAChT-Q.UAS under the control of Scer\GAL4ChAT.7.4 in third instar larval aCC/RP2 motoneurons leads to a significant increase in the duration of optogenetically (using Crei\ChR2UAS.cSa) evoked EPSCs and a significant increase in the amplitude ratio between the first and second EPSC optogenetically evoked (at a following frequency of 1 Hz) compared to controls.

      (Vernon et al., 2019)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      VAChT-Q.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)