FlyBase Allele Report: Dmel\Traf-like[Δ]

General Information

Symbol

Dmel\Traf-like^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0344128

Feature type

allele

Associated gene

Dmel\Traf-like

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Lee et al., 2018)

Progenitor genotype

Cytology

Description

1kb deletion that removes most of the Traf-like coding sequence.

(Lee et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage

(Lee et al., 2018)

increased mortality | adult stage | conditional

(Lee et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Traf-like^Δ homozygotes exhibit significantly higher mortality to Ecc15 enteric infection, as compared to controls.

(Lee et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Traf-like^Δ has increased mortality | adult stage | conditional phenotype, suppressible by Acc^KK102082/Scer\GAL4^hs.PB

(Lee et al., 2018)

Traf-like^Δ has abnormal immune response | adult stage phenotype, suppressible by Acc^KK102082/Scer\GAL4^hs.PB

(Lee et al., 2018)

Traf-like^Δ has increased mortality | adult stage | conditional phenotype, suppressible by bmm^UAS.cUa/Scer\GAL4^hs.PB

(Lee et al., 2018)

Traf-like^Δ has abnormal immune response | adult stage phenotype, suppressible by bmm^UAS.cUa/Scer\GAL4^hs.PB

(Lee et al., 2018)

Traf-like^Δ has increased mortality | adult stage | conditional phenotype, suppressible by Scer\GAL4^NP0001/G6pd^UAS.cLa

(Lee et al., 2018)

Traf-like^Δ has abnormal immune response | adult stage phenotype, suppressible by Scer\GAL4^NP0001/G6pd^UAS.cLa

(Lee et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Traf-like^Δ/Traf-like^Δ is a suppressor of endosome | adult stage phenotype of Cad99C^UAS.GFP, Scer\GAL4^NP0001

(Lee et al., 2018)

Traf-like^Δ/Traf-like^Δ is a suppressor of adult enterocyte phenotype of Cad99C^UAS.GFP, Scer\GAL4^NP0001

(Lee et al., 2018)

Traf-like^Δ/Traf-like^Δ is a suppressor of endosome | adult stage | conditional phenotype of Cad99C^UAS.GFP, Scer\GAL4^NP0001

(Lee et al., 2018)

Traf-like^Δ/Traf-like^Δ is a suppressor of adult enterocyte | conditional phenotype of Cad99C^UAS.GFP, Scer\GAL4^NP0001

(Lee et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The Scer\GAL4^NP0001>Cad99C^UAS.GFP-induced Cad99C^UAS.GFP-positive endosome formation in adult enterocytes is abolished by Traf-like^Δ homozygosity; the enhanced endosome formation upon Ecc15 enteric infection is also abolished by Traf-like^Δ homozygosity.

(Lee et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Traf-like^Δ is rescued by Scer\GAL4^NP0001/Traf-like^UAS.Tag:V5

(Lee et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

TRAF3^Δ

(Lee et al., 2018)

Traf-like^Δ

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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