FlyBase Allele Report: Dmel\prc[3-21]

General Information

Symbol

Dmel\prc^3-21

Species

D. melanogaster

Name

FlyBase ID

FBal0344464

Feature type

allele

Associated gene

Dmel\prc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Wilmes et al., 2018)

Mutagen

ethyl methanesulfonate

(Wilmes et al., 2018)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage

(Wilmes et al., 2018)

abnormal size | third instar larval stage (with Df(3L)vin6)

(Wilmes et al., 2018)

abnormal size | third instar larval stage (with prc^3-548)

(Wilmes et al., 2018)

abnormal size | third instar larval stage (with prc^MB03017)

(Wilmes et al., 2018)

fertile (with Df(3L)vin6)

(Wilmes et al., 2018)

fertile (with prc^3-548)

(Wilmes et al., 2018)

fertile (with prc^MB03017)

(Wilmes et al., 2018)

lethal - all die before end of pupal stage

(Wilmes et al., 2018)

viable (with Df(3L)vin6)

(Wilmes et al., 2018)

viable (with prc^3-548)

(Wilmes et al., 2018)

viable (with prc^MB03017)

(Wilmes et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

prc^3-21 homozygous, prc^3-21/prc^3-548 and prc^3-21/prc^MB03017 larvae have a cardiac phenotype consisting of detached pericardial cells, severely misguided myofibers and severe heart tube luminal collapse resulting in a significantly reduced heart diameter.

(Wilmes et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

prc^MB03017/prc^3-21 is partially rescued by prc^+t32

(Wilmes et al., 2018)

Not rescued by

prc^MB03017/prc^3-21 is not rescued by prc^{fTRG00497.sfGFP-TVPTBF}

(Wilmes et al., 2018)

Comments

prc^+t32 partially rescues the dissociation of pericardial cells from the heart in prc^3-21/prc^MB03017 transheterozygous larvae.

(Wilmes et al., 2018)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PMM3-21

(Wilmes et al., 2018)

pericardin^3-21

(Wilmes et al., 2018)

prc^3-21

(Wilmes et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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