- Tools
- Downloads
- Links
- Community
- About
- Help
FB2026_01
,
released March 12, 2026
Pc
collagen-like extracellular matrix protein involved in heart development
Please see the JBrowse view of Dmel\prc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Apparent introns not annotated: probable artifacts due to repetitive sequence.
Low-frequency RNA-Seq exon junction(s) not annotated.
Most of large exon composed of repeat unit.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\prc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
prc was shown to be expressed through development by northern blots with the highest levels in embryos and first and second instar larvae. From stage 13 onwards, it is expressed in cardioblasts and pericardial cells as well as in oenocytes. Expression is also observed in the ring gland.
Comment: precursor
prc protein is found predominantly along the basal side of cardial cells (cardiomyocytes). It colocalizes with loh protein. It forms an integral part of the basal cardiac extracellular matrix. In larvae, it is mainly produced in the fat body. prc is locally produced by cardiac cells in embryos but in later stages is mostly secreted by the fat body.
prc protein is expressed in pericardial cells at all developmental stages.
prc is located around the periphery of pericardial cells and at the the basal surface of the cardioblasts in close proximity to the ectoderm in embryonic stages 14,15. It is particularly abundant at the boundary between the cardioblasts and the dorsal epithelium. It is also expressed in two of every six cardial cells that correspond to the svp-expressing cells and in the attachment sites to the alary muscles. By stage 17, prc is detectable only in the extracellular space around the pericardial cells and on the basal surface of cardiomyocytes.
prc protein is localized to the basal membranes of embryonic/larval cardial cells (cardiomyocytes).
JBrowse - Visual display of RNA-Seq signals
View Dmel\prc in JBrowse
3-37
3-30.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
prc is involved in the morphogenesis and maintenance of the heart epithelium during dorsal ectoderm closure.
Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
Source for merge of: prc CG5700
Source for merge of: prc BEST:CK01593
The expression pattern of the "Mab3" epitope is identical to the expression pattern recognised by the "EC11" antibody (which recognises "prc"), so it is possible that the "Mab3" epitope corresponds to part of the "prc" protein (although this has not been tested).
