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Bataill√©, L., Colombi√©, N., Pelletier, A., Paululat, A., Lebreton, G., Carrier, Y., Frendo, J.L., Vincent, A. (2020). Alary muscles and thoracic alary-related muscles are atypical striated muscles involved in maintaining the position of internal organs.  Development 147(8): dev185645.
FlyBase ID
FBrf0245465
Publication Type
Research paper
Abstract

Alary muscles (AMs) have been described as a component of the cardiac system in various arthropods. Lineage-related thoracic muscles (TARMs), linking the exoskeleton to specific gut regions, have recently been discovered in Drosophila. Asymmetrical attachments of AMs and TARMs, to the exoskeleton on one side and internal organs on the other, suggested an architectural function in moving larvae. Here, we analysed the shape and sarcomeric organisation of AMs and TARMs, and imaged their atypical deformability in crawling larvae. We then selectively eliminated AMs and TARMs by targeted apoptosis. Elimination of AMs revealed that AMs are required for suspending the heart in proper intra-haemocelic position and for opening of the heart lumen, and that AMs constrain the curvature of the respiratory tracheal system during crawling; TARMs are required for proper positioning of visceral organs and efficient food transit. AM/TARM cardiac versus visceral attachment depends on Hox control, with visceral attachment being the ground state. TARMs and AMs are the first example of multinucleate striated muscles connecting the skeleton to the cardiac and visceral systems in bilaterians, with multiple physiological functions.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Alleles (28)
    Genes (15)
    Natural transposons (2)
    Insertions (13)
    Experimental Tools (6)
    Transgenic Constructs (22)
    Transcripts (1)