The expression of Diedel^dsRNA.UAS under the control of Scer\GAL4^Cg.PA leads to adult midgut defects, namely enterocyte detachment from the basement membrane and increased apoptosis.

The adult midgut of individuals expressing Diedel^dsRNA.UAS under the control of Scer\GAL4^ppl.PP or Scer\GAL4^Cg.PA, but not Scer\GAL4^Act88F.1.3, shows a significantly higher age-dependent increase in mitosis than controls. The Scer\GAL4^Cg.PA-driven expression also leads to the midgut showing significantly higher apoptosis in 20-days old adults, but not 10- and 40-days old, adults than in controls. The Scer\GAL4^ppl.PP-driven expression leads to a significant increase in apoptosis in the midgut of 30-days old adults, as compared to controls.

Adulthood-only expression under the control of Scer\GAL4^{αTub84B.Switch.PK} and RU486 feeding leads to a RU486 concentration-dependent decrease in lifespan.