FlyBase Allele Report: Dmel\Sce[c244]

General Information

Symbol

Dmel\Sce^c244

Species

D. melanogaster

Name

FlyBase ID

FBal0345111

Feature type

allele

Associated gene

Dmel\Sce

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Yang et al., 2019, Ma et al., 2018)

Progenitor genotype

Cytology

Description

244bp deletion within Sce.

(Ma et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:27,681,550..27,681,793 [-]

Comment:

244bp deletion within Sce. Deletion boundaries mapped from reported border sequences.

(Ma et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior

(Yang et al., 2019)

abnormal oxidative stress response

(Yang et al., 2019)

lethal | recessive

(Yang et al., 2019)

long lived | female

(Yang et al., 2019)

long lived | male

(Yang et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sce^c244/+ flies live significantly longer, perform markedly better in a climbing test and show increased survival rates when exposed to oxidative stress compared to wild-type controls. Food intake in adults is similar to controls.

(Yang et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sce^c244 has long lived | male phenotype, enhanceable by Su(z)2^c433/Su(z)2[+]

(Yang et al., 2019)

Sce^c244 has long lived | female phenotype, enhanceable by Su(z)2^c433/Su(z)2[+]

(Yang et al., 2019)

Sce^c244 has abnormal locomotor behavior phenotype, enhanceable by Su(z)2^c433/Su(z)2[+]

(Yang et al., 2019)

Sce^c244 has abnormal oxidative stress response phenotype, enhanceable by Su(z)2^c433/Su(z)2[+]

(Yang et al., 2019)

Enhancer of

Statement

Reference

Sce^c244/Sce[+] is an enhancer of long lived | male phenotype of Su(z)2^c433

(Yang et al., 2019)

Sce^c244/Sce[+] is an enhancer of long lived | female phenotype of Su(z)2^c433

(Yang et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Sce^c244

(Yang et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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