FlyBase Allele Report: Dmel\Su(z)2[c433]

General Information

Symbol

Dmel\Su(z)2^c433

Species

D. melanogaster

Name

FlyBase ID

FBal0345104

Feature type

allele

Associated gene

Dmel\Su(z)2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Yang et al., 2019, Ma et al., 2018)

Progenitor genotype

Cytology

Description

433bp deletion within Su(z)2.

(Ma et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:12,999,850..13,000,282 [+]

Comment:

433bp deletion within Su(z)2. Deletion boundaries mapped from reported border sequences.

(Ma et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Yang et al., 2019)

long lived | dominant

(Ma et al., 2018)

long lived | female

(Yang et al., 2019)

long lived | male

(Yang et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Su(z)2^c433/+ males and females live significantly longer than wild-type controls. Their food intake is similar to controls.

(Yang et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Su(z)2^c433 has long lived | male phenotype, enhanceable by Sce^c244/Sce[+]

(Yang et al., 2019)

Su(z)2^c433 has long lived | female phenotype, enhanceable by Sce^c244/Sce[+]

(Yang et al., 2019)

Enhancer of

Statement

Reference

Su(z)2^c433/Su(z)2[+] is an enhancer of long lived | male phenotype of Sce^c244

(Yang et al., 2019)

Su(z)2^c433/Su(z)2[+] is an enhancer of long lived | female phenotype of Sce^c244

(Yang et al., 2019)

Su(z)2^c433/Su(z)2[+] is an enhancer of abnormal locomotor behavior phenotype of Sce^c244

(Yang et al., 2019)

Su(z)2^c433/Su(z)2[+] is an enhancer of abnormal oxidative stress response phenotype of Sce^c244

(Yang et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Su(z)2^c433

(Yang et al., 2019, Ma et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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