Mutations that increase the affinity of the aop SAM domain for self-association have been introduced into the endogenous aop locus; the changes are R92K and G96R. Each mutation converts the wild-type aop residue to the equivalent residue found in the orthologous human ETV6 gene (HGNC:3495).
aopSY3 adults show a rough eye phenotype; ommatidia show some extra photoreceptor cells, namely outer photoreceptor cells, and rare missing photoreceptor cells, as compared to controls.
