FB2026_02 , released June 18, 2026
Allele: Dmel\aopSY4
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General Information
Symbol
Dmel\aopSY4
Species
D. melanogaster
Name
FlyBase ID
FBal0345228
Feature type
allele
Associated gene
Dmel\aop
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Hope et al., 2018)
Mutagen
CRISPR/Cas9
(Hope et al., 2018)
gene targeting by homologous recombination
(Hope et al., 2018)
Progenitor genotype
Cytology
Description

Mutations that increase the affinity of the aop SAM domain for self-association have been introduced into the endogenous aop locus; the changes are R92K, A93E and G96R. Each mutation converts the wild-type aop residue to the equivalent residue found in the orthologous human ETV6 gene (HGNC:3495).

(Hope et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dead aopSY4 embryos present defects in the anterior portion of the head cuticle. Adults show a rough eye phenotype; ommatidia show some extra photoreceptor cells, namely outer photoreceptor cells, and rare missing photoreceptor cells, as compared to controls.

      (Hope et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      aopSY4
      yanSY4
      (Hope et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)